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Inhibition of SARS-CoV-2 3CLpro by a non-competitive mechanism. Lineweaver–Burk plots of kinetics experimental data for inhibition of the SARS-CoV-2 3CLpro by JMX0286, JMX0301 and JMX0941 (A–C). The SARS-CoV-2 3CLpro at 200 nM was mixed with DMSO, JMX0286, JMX0301, or JMX0941 (5 μM or 10 μM) for 30 min. Substrate Edan was added at various concentrations (120 μM–1 μM).
