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. 2022 Jun 27;13:893365. doi: 10.3389/fimmu.2022.893365

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Copyright © 2022 Radovani and Gudelj

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the biosynthesis of N-glycans involved in the fine-tuning of the immune response to inflammation. The schematic includes the major N-glycan structures found on the surface of endothelium, immune cells, and secreted molecules, along with the relevant glycosyltransferases, whose expression has been shown to be modulated by inflammatory cytokines, dramatically affecting glycan-dependent interactions important for leukocyte immune regulation. B4GALT1, Beta-1,4-Galactosyltransferase 1; FUT, Fucosyltransferase; GCNT2, Glucosaminyl (N-acetyl) Transferase 2; MGAT, N-acetylglucosaminyltransferase; ST6GAL4, Beta-Galactoside Alpha-2,3-Sialyltransferase 4; ST6GAL1, Beta-Galactoside Alpha-2,6-Sialyltransferase 1.