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. Author manuscript; available in PMC: 2022 Jul 11.
Published in final edited form as: Nature. 2022 May 11;605(7910):497–502. doi: 10.1038/s41586-022-04701-5

Extended Data Fig. 5 |. 3-mer mutation sequence contexts enriched in DBA/2J-like Mouse Genomes Project strains.

Extended Data Fig. 5 |

For each mutation type defined by its 3-mer sequence context, we can compute its Log-2 compositional enrichment in BXD strains with D vs. B haplotypes at the QTL on chromosome 4, as well as its log-2 compositional enrichment in Sanger Mouse Genomes Project strains that are D-like vs. B-like. These two odds ratios are correlated, indicating that the same mutational signature is enriched in the BXD D strains and the D-like Sanger MGP strains. Mutation types significantly enriched in BXDs with D haplotypes are colored red, outlined in black and labeled.