Locomotor behavior characterization of aging single and double knockout mice. Open field measurements of locomotor activity across total session including; activity count (A), fine movement count (B); rearing count (C); ambulatory activity count (D); ambulatory frequency (E; stereotypy measure); and path length (F). Accelerating rotarod to show differences in motor performance and learning for each age: 6 to 11 (G), 12 to 17 (H), and 18 to 24 month (I). * p<0.05 vs. WT 18 to 24 month, ^ p<0.05 vs. 6 to 1 lmonth, + p<0.05 vs. Day 1, and - p<0.05 vs. Day 2.