Skip to main content
. Author manuscript; available in PMC: 2022 Oct 19.
Published in final edited form as: J Am Coll Cardiol. 2021 Oct 19;78(16):1603–1617. doi: 10.1016/j.jacc.2021.08.024

Central Illustration: Distinct Features of J Wave Syndrome (JWS) Carrying SCN5A Pathogenic Variants.

Central Illustration:

A: Topology of SCN5A and location of pathogenic variants revealed in Early Repolarization Syndrome (ERS) probands of the present study. The ball with a thermometer indicates mutant carrier is unmasked by fever. B: The percentage yield of SCN5A+ pathogenic variants in BrS and ERS probands. SCN5A is a major susceptibility gene in ERS as in BrS, whereas the yield in ERS is significantly lower than in BrS. C: The percentage yield of probands exhibiting major arrhythmic events (MAE) among JWS probands carrying single pathogenic variant and multiple pathogenic variants limited to SCN5A gene.