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. Author manuscript; available in PMC: 2022 Oct 19.
Published in final edited form as: J Am Coll Cardiol. 2021 Oct 19;78(16):1603–1617. doi: 10.1016/j.jacc.2021.08.024

Table 4.

Clinical characteristic of probands with single or multiple pathogenic variants in SCN5A

SPV (N=65) MPV (N=5) p-value

Age (years) 37.31±18.64 26.08±18.82 0.199
Children (age<16 years) 10 (15.38%) 2 (40.00%) 0.201
Family history, n (%) 22 (33.85%) 2 (40.00%) 1.000
CCD, n (%) 25 (38.46%) 3 (60.00%) 0.383
Bradycardia, n (%) 15 (23.08%) 2 (40.00%) 0.589
Syncope, n (%) 35 (53.85%) 3 (60.00%) 1.000
fQRS, n (%) 15 (23.08%) 2 (40.00%) 0.589
Global J wave, n (%) 16 (24.62%) 1 (20.00%) 1.000
MAE, n (%) 18 (27.69%) 4 (80.00%) 0.031
HR (bpm) 74.63±18.62 75.99±21.38 0.936
QRS duration (ms) 102.23±19.68 123.56±11.03 0.041
PR interval (ms) 181.24±32.31 214.50±16.24 <0.001
P wave duration (ms) 106.79±20.86 108.92±18.97 0.912
QTc interval (II, ms) 419.95±44.26 427.13±25.09 0.574
QTc interval (V5, ms) 421.43±47.81 428.77±11.92 0.611
Tp-e (II, ms) 91.63±19.62 97.42±5.77 0.320
Tp-e /QT (II, ms) 0.237±0.040 0.235±0.020 0.982
Tp-e (V5, ms) 93.78±23.17 105.92±3.653 0.224
Tp-e /QT (V5, ms) 0.241±0.044 0.253±0.004 0.179

Note: SPV and MPV represent single and multiple pathogenic variant(s), respectively.