Figure 5.

Phenome-wide association study of polygenic risk scores for Consumption (left panel) and Problems (right panel) against 1,338 diseases available in the biobank from Vanderbilt University Medical Center, BioVU. PheWAS of both Consumption and Problems revealed positive genetic associations with alcohol use disorders. Problems was positively genetically associated with multiple psychiatric conditions, whereas Consumption was counterintuitively negatively associated with metabolic conditions. Importantly, most of the associations disappear when adjusting for alcohol use disorders diagnosis (non-significant associations are highlighted in gray).