Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 6;54(1):1867–1883. doi: 10.1080/07853890.2022.2089728

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 1. — Representative DTI-fibre tracking longitudinal results of injured and NT3-chitosan treated animals. Data processing just following the same methods as we previously reported [26]. (A) Reconstructed fibre bundles were superimposed on the corresponding axial PD weighted structural images. Before operation, the structure of the spinal cord exhibited good integrity, and the fibre bundles filled the whole spinal cord structure in an orderly manner. After operation, the tissue of the right thoracic cord was damaged and the structural integrity was destroyed, and the implanted NT3–chitosan scaffold could be clearly observed. The fibres (rostrocaudal orientation) gradually extended across the surgical site over time, reconnecting the rostral and caudal ends of the injured cord in the regenerative therapy animals. On the axial structural images, the material boundary gradually blurred and disappeared with the degradation of the implanted NT3-chitosan scaffold. In injured animals, no fibre bundles were present within the lesion and passed through the injured site. (B) The proportion of the regenerated fibres to the number of remote normal-like spinal cord fibres was significantly different between the two groups at 3, 6, and 12 months post-SCI (Independent t-test with Bonferroni multiple comparisons). m, months.