Skip to main content
. 2022 Jul 6;54(1):1867–1883. doi: 10.1080/07853890.2022.2089728

Figure 2.

Figure 2.

The injured and NT3-chitosan-treated animals have different brain functional reorganization features. (A) Causal interactions that significantly deviated from intact status in each timepoint post-SCI were superimposed on the three-dimensional monkey brain. The corresponding quantitative assessment described the alteration of intensity (Paired t-test with Bonferroni multiple comparisons). Red indicates the GCA intensity that is significantly higher than the intact state, whereas blue indicates the opposite. Box plots show the median and 25th and 75th percentiles; whiskers indicate the minimum and maximum values. Raw data were shown in graphs. The green ball represents both ends of the brain regions of the causal interaction, and the arrows indicate the direction of information flow. (B) Significant difference between the two groups in the proportion of subcortical regions involved in the reorganization (Independent t-test). (C) Notable difference between the two groups in the ratio of GCA originating from the left brain regions (Independent t-test). Data dots represent the proportion at each timepoint post-SCI. (D) The two group animals differed in the proportions of intra- and inter-hemispheric GCA alterations at early and late stages (Chi-square test). L: left; R: right; m: months; S1l: lateral primary somatosensory cortex; M1l: lateral primary motor cortex; Pu: putamen; MOG: middle occipital gyrus; MFG: middle frontal gyrus; M1m: medial primary motor cortex; Ins: insula; PE area: parieto-occipital association cortex; Th: thalamus; S2: secondary somatosensory cortex; SMA: supplementary motor area; S1m: medial primary somatosensory cortex. Injured group: ①L.S1l→L.M1l, ②L.Pu→R.MOG, ③R.M1l→R.MFG, ④R.M1m→L.Ins, ⑤L.MOG→L.S1l, ⑥L.PE area→L.MFG, ⑦R.M1l→L.S1l, ⑧R.S1l→L.Th, ⑨R.MOG→R.S2, ⑩R.S1l→R.Th, ⑪R.Pu→L.S1l, ⑫L.S1l→R.S2, ⑬R.PE area→R.Pu, ⑭R.M1m→R.S1l, ⑮L.S2→R.S2, ⑯L.Pu→R.M1l. NT3-chitosan group: (1)L.Ins→L.MFG, (2)L.SMA→L.S1m, (3)L.SMA→L.M1m, (4)R.PE area→L.M1l, (5)L.S1m→R.MOG, (6)L.S1m→R.MFG, (7)L.M1m→R.MFG, (8)L.SMA→R.M1m, (9)L.SMA→R.SMA, (10)L.S1m→R.PE area, (11)L.M1l→L.S1l, (12)R.S1l→R.MOG.