Table 1.

The antiproliferative effects of the target compounds and parent compounds against different cell lines.

Compound	aIC50 (μM)
	A549	MCF-7	MDA-MB-231	MCF-10A	bSIMCF-7	cSIMDA-MB-231
7Aa	15.25 ± 1.37	26.43 ± 1.25	31.51 ± 2.77	>50	>1.89	>1.58
7Ab	9.41 ± 0.68	15.31 ± 0.94	29.58 ± 1.80	>50	>3.27	>1.69
7Ac	2.33 ± 0.15	5.87 ± 0.42	1.62 ± 0.15	21.54 ± 0.88	3.67	13.30
7Ba	9.84 ± 0.47	18.96 ± 1.33	24.22 ± 1.97	>50	>2.64	>2.06
7Bb	4.91 ± 0.30	19.67 ± 1.28	16.45 ± 1.55	>50	>2.54	>3.04
7Bc	5.05 ± 0.21	12.18 ± 0.92	18.73 ± 0.61	>50	>4.11	>2.67
7Ca	2.97 ± 0.14	2.55 ± 0.14	2.26 ± 0.19	40.68 ± 2.79	15.95	18
7Cb	3.53 ± 0.29	4.68 ± 0.39	1.47 ± 0.14	36.71 ± 1.02	7.84	24.97
7Cc	1.94 ± 0.05	1.75 ± 0.15	0.82 ± 0.02	27.53 ± 2.34	15.73	33.57
7Da	2.79 ± 0.07	1.80 ± 0.11	0.92 ± 0.01	24.74 ± 1.67	13.74	26.89
7Db	3.92 ± 0.31	2.94 ± 0.27	3.11 ± 0.22	39.47 ± 2.90	13.43	12.69
7Dc	1.63 ± 0.05	2.18 ± 0.10	1.88 ± 0.09	19.85 ± 1.43	9.11	10.56
7Ea	4.62 ± 0.16	25.33 ± 0.90	19.00 ± 0.70	43.61 ± 2.65	2.79	2.30
7Eb	4.55 ± 0.43	17.89 ± 1.26	41.46 ± 1.48	>50	>2.79	>1.21
7Ec	4.81 ± 0.18	3.94 ± 0.28	1.81 ± 0.13	48.32 ± 3.78	12.26	26.70
Cisplatin	4.97 ± 0.37	dNT	dNT	dNT	eNC	eNC
Adriamycin	dNT	5.12 ± 0.31	4.92 ± 0.44	dNT	eNC	eNC

^aIC₅₀: half inhibitory concentrations measured by the CCK-8 assay. The values are expressed as average ± standard deviation of three independent experiments.

^bSI_MCF-7: selectivity index between MCF-7 and MCF-10A. It was calculated as: SI = IC_50(MCF-10A)/IC_50(MCF-7).

^cSI_MDA-MB-231: selectivity index between MCF-7 and MDA-MB-231. It was calculated as: SI = IC_50(MCF-10A)/IC_{50(MDA-MB-231)}.

^dNT: not tested.

^eNC: not calculated.