Table 2.

Mitral Regurgitation in Relation to Sub-papillary and Remote LV Contractile Function Among Patients with Ischemia

2a.
		Mitral Regurgitation
	Overall (n=532)	None (n=348)	Mild (n=147)	≥Moderate (n=37)	p
Wall Motion Score
Global	4.5 ± 8.3	2.9 ± 6.5	6.1 ± 9.4	12.9 ± 12.4	<0.001
Sub-papillary	2.5 ± 4.5	1.6 ± 3.5	3.4 ± 5.1	7.1 ± 6.4	<0.001
Non-papillary	1.8 ± 3.5	1.2 ± 2.8	2.4 ± 4.0	4.9 ± 5.6	<0.001
Number of Dysfunctional Segments
Global	3.0 ± 5.0	2.1 ± 4.1	4.3 ± 5.8	7.4 ± 6.1	<0.001
Sub-papillary	1.6 ± 2.5	1.0 ± 2.1	2.2 ± 2.9	4.0 ± 3.1	<0.001
Non-papillary	1.5 ± 2.6	1.0 ± 2.2	2.1 ± 3.1	3.5 ± 3.3	<0.001
Radial Strain
Global	61.2 ± 24.4%	66.0 ± 22.0%	56.5 ±25.4%	36.7 ± 23.1%	<0.001
Sub-papillary	62.1 ± 27.0%	66.9 ± 24.7%	57.8 ± 28.3%	35.9 ± 24.6%	<0.001
Non-papillary	60.3 ± 24.9%	65.2 ± 22.8%	55.1 ± 25.4%	37.5 ± 24.7%	<0.001

2b.
FMR severity		Region	Multivariable OR	95% CI	p
≥Moderate versus None	Wall Motion Score	Sub-papillary	1.24	[1.09, 1.41]	0.001
		Non-papillary	0.97	[0.82, 1.14]	0.69
Mild versus None	Wall Motion Score	Sub-papillary	1.11	[1.01, 1.21]	0.03
		Non-papillary	1.00	[0.89, 1.12]	0.93

2c.
FMR severity		Region	Multivariable OR	95% CI	p
≥Moderate versus None	Radial Strain (per 5% decrement)	Sub-papillary	1.22	[1.07, 1.38]	<0.01
		Non-papillary	1.12	[0.99, 1.26]	0.08
Mild versus None	Radial Strain (per 5% decrement)	Sub-papillary	1.11	[1.01, 1.21]	0.03
		Non-papillary	1.00	[0.89, 1.12]	0.93

Analysis limited to patients with inducible perfusion defects on stress CMR and minimal infarction (≤ 5% LV myocardium, non-transmural) on LGE-CMR (n=532). All multivariable models include only the variables displayed – sub-papillary and non-papillary wall motion (2b) and radial strain (2c) respectively.