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. 2022 Jun 23:eabq4450. doi: 10.1126/sciimmunol.abq4450

Fig. 3. Antigenic maps comparing neutralizations with SARS-CoV-2 pseudoviruses and authentic SARS-CoV-2.

Fig. 3.

(A-B) MDS was used to create an antigenic map from the PRNT50 titers generated against 614D, 614G, Alpha, Beta, Delta, Kappa and Omicron pseudoviruses on either VeroE6 (A) or Calu-3 (B) cells. (C) MDS was used to create an antigenic map from the PRNT50 titers generated against 614G, Alpha, Beta, Delta and Omicron authentic SARS-CoV-2. (D) Re-display of antigenic map in C with lilac arrows indicating antigen positions in map A and black arrows indicating antigen positions in map B. Viruses are shown as colored circles and antisera as squares with the same outline color as the matching viruses. Viruses and antisera are positioned in the map so that the distances between them are inversely related to the antibody titers, with minimized error. The grid in the background scales to a 2-fold dilution of antisera in the titrations. MDS: multidimensional scaling. PRNT50: plaque reduction neutralization titers resulting in 50% plaque reduction.

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