Table 2. Neutralization potency of IMM20184, IMM20253 antibodies and IMM20184/253 antibody combination against Omicron BA.1 and BA.2 virus isolates in a plaque reduction assay.
Denoted IC50 (nM) values for WA1/2020 and Omicron BA.1 are Means from two and three independent experiments. Denoted IC50 (nM) values for BA.2 are means of three replicates from a single experiment.
| Antibody |
WA1/2020
(N=2) |
Omicron BA.1 (N=3) | Omicron BA.2 (N=1) |
| IMM20184 | 81.5 | >1000 | >1000 |
| IMM20253 | 27.3 | 48.2 | 28.3 |
| IMM20184/IMM20253 | 19.0 | 16.7 | 2.7 |