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. 2022 Jun 28;18(6):e1010272. doi: 10.1371/journal.pgen.1010272

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© 2022 Arévalo et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A) Schematic representation of the generation of cP2 deletion. Double strand breaks induced by Cas9 indicated by black triangles. (B) Schematic overview of analyzed genotypes and fertility. Prm2^+/- and Prm2^-/- [6] were included as a comparison. Bar plot of average litter size for WT, Prm2^+/-, Prm2^-/-, Prm2^+/Δc and Prm2^-/Δc, n = 5 for each genotype. (C) Bar plot showing average DESeq2 normalized read counts of Prm2 for WT, Prm2^+/Δc and Prm2^-/Δc. (D) Bar plot showing comparison between number of differentially higher and lower expressed genes for Prm2^+/Δc and Prm2^-/Δc compared to wildtype.