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. 2022 Jun 28;18(6):e1010272. doi: 10.1371/journal.pgen.1010272

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© 2022 Arévalo et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — (A) volcano plots showing differential abundance (DA) of basic nuclear proteins in Prm2^+/Δc compared to WT (upper plot) and Prm2^-/Δc compared to WT (lower plot). Significantly DA proteins are indicated in color (teal = lower abundant, yellow = higher abundant). Top DA proteins and proteins of interest are labeled with their corresponding gene symbol. (B) Venn diagram showing the overlap between DA proteins found in the three different comparisons (WT vs. Prm2^+/Δc, WT vs. Prm2^-/Δc and WT vs. Prm2^-/-). Proteins present in overlaps of interest are listed with their corresponding gene symbol. H2A.L.2 is marked in red. (C) Boxplot of median normalized log2 abundance of H2A.L.2 in WT, Prm2^-/-, Prm2^+/Δc and Prm2^-/Δc. (D) Immunoblots against H2A.L.2 and ODF2 as a control in testis (WT), caput epididymis (caput) and mature sperm (sperm) basic nuclear protein extractions (WT, Prm2^+/Δc and Prm2^-/Δc).