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. Author manuscript; available in PMC: 2022 Jul 11.
Published in final edited form as: Prog Biomed Eng (Bristol). 2021 Sep 30;3(4):042006. doi: 10.1088/2516-1091/ac23a4

Figure 1.

Figure 1.

The diverse and multi-fold roles of blood clots. Among them, (A) blood clots occlude the initial wound site to stop hemorrhage. Additionally, blood clot constituents, such as platelets, release chemokines that attract immune cells. (B) As wound healing progresses, blood clots also provide a substrate for migrating matrix-synthesizing cells to infiltrate the clot and remodel the clot’s fibrin mesh with collagen. (C) Eventually, the blood clot is replaced by the repaired tissue. Reprinted by permission from Springer Nature Customer Service Centre GmbH: Springer Nature, Pediatric Research [10], Copyright © 2013, International Pediatric Research Foundation, Inc.