Table 2.
Impact on Non-LDL Laboratories
| Study | Non-HDL Lowering | TC Lowering | TG Lowering | HDL Increasing | hs-CRP Lowering |
|---|---|---|---|---|---|
| EXPLORER14 | RSV/EZ: 65 RSV: 52 p<0.001 |
RSV/EZ: 51a RSV: 42 p<0.001 |
RSV/EZ: 35 RSV: 25 p<0.001 |
RSV/EZ: 11 RSV: 9 p=0.151 |
RSV/EZ: 46 RSV: 29 p<0.001 |
| MRS-ROZE16 | RSV/EZ: 54.9 RSV: 45.8 p<0.001 |
RSV/EZ: 39.6a RSV: 32.9 p<0.001 |
RSV/EZ: 22.7 RSV: 13.4 p=0.003 |
RSV/EZ: 14.1 RSV: 11.7 p=0.171 |
NR |
| I-ROSETTE17 | RSV/EZ: 53.2 RSV: 42.2 p<0.001 |
RSV/EZ: 38.8b RSV: 30.2 p<0.001 |
RSV/EZ: 19.2 RSV: 11.9 p=0.024 |
RSV/EZ: 13.6 RSV: 11.3 p=0.200 |
NR |
| Kim W18 | RSV/EZ: 52.8 RSV: 41.4 p<0.01 |
RSV/EZ: 39.0b RSV: 30.7 p<0.01 |
RSV/EZ: 19.9 RSV: 9.4 p<0.05 |
RSV/EZ: 10.8 RSV: 9.4 p=0.14 |
RSV/EZ: 69.4 RSV: 66.1 p=0.95 |
| Hwang20 | RSV/EZ: 100.8 RSV: 98.9 p=0.79 |
RSV/EZ: 98.4a RSV: 99 p=0.77 |
RSV/EZ: 49.5 RSV: 10.5 p=0.01 |
RSV/EZ: 0.5 RSV: 0.5 p=0.99 |
RSV/EZ: 0.15 RSV: 0.49 p=0.35 |
| Torimoto21 | NR | NR | RSV/EZ: 13.8c RSV: 1.3 p=0.032 |
RSV/EZ: 1.1 RSV: 2.4 p=0.408 |
NR |
| Masuda22 | RSV/EZ: 50.3b RSV: 34.8 p=0.037 |
RSV/EZ: 35.8 RSV: 25.2 p=0.048 |
RSV/EZ: 17.5 RSV: 4.6 p=0.029 |
RSV/EZ: 8.8 RSV: 4.3 p=0.490 |
RSV/EZ: 18.8 RSV: 14.4 p=0.764 |
| Bays19 | RSV/EZ: 17.1c RSV: 5.2 p<0.001 |
RSV/EZ: 12.6 RSV: 3.9 p<0.001 |
RSV/EZ: 6.3 RSV: 3.2 p=NS |
RSV/EZ: −0.5 RSV: 1.7 p=NS |
RSV/EZ: 14.1 RSV: 13.0 p=NS |
| Ambegaonkar25 | Prior ST/EZ: 22.6d ST DD: 8.5 RSV: 16.3 SIM/EZ: 22.8 |
Prior ST/EZ: 12.1 ST DD: 5.0 RSV: 5.7 SIM/EZ: 8.0 |
Prior ST/EZ: 1.7 ST DD: 0.8 RSV: 3.2 SIM/EZ: 2.5 |
||
| GRAVITY26 | RSV/EZ 10/10: 54.7a RSV/EZ 20/10: 58.9 SIM/EZ 40/10: 49.9 SIM/EZ 80/10: 52.4 |
RSV/EZ 10/10: 43.0 RSV/EZ 20/10: 46.6 SIM/EZ 40/10: 39.6 SIM/EZ 80/10: 41.7 |
RSV/EZ 10/10: 28.9 RSV/EZ 20/10: 35.0 SIM/EZ 40/10: 23.0 SIM/EZ 80/10: 25.8 |
RSV/EZ 10/10: 6.4 RSV/EZ 20/10: 7.5 SIM/EZ 40/10: 3.9 SIM/EZ 80/10: 4.3 |
RSV/EZ 10/10: 25.2 RSV/EZ 20/10: 34.1 SIM/EZ 40/10: 28.5 SIM/EZ 80/10: 30.6 |
Notes: aData represented as mean change in mg/dL. bData represented as percent change from baseline. cData represented as least squares mean in mg/dL. dData represented as percent change from baseline as a least squares mean.
Abbreviations: RSV, rosuvastatin; EZ, ezetimibe; SIM, simvastatin; LDL, low-density lipoprotein; HDL, high-density lipoprotein; TC, total cholesterol; TG, triglycerides; hs-CRP, high sensitivity c-reactive protein.