Figure 3.

Significantly upregulated genes in patients with severe COVID-19 compared with patients with mild COVID-19 and control participants in both a single-cell RNA sequencing study¹⁵ and the current study

The pink boxes denote genes that are upregulated in the severe cohort as compared with the mild cohort in both stem-cell RNA sequencing and plasma proteomics analysis. T cell 1, T cell 2, plasma cells, macrophages, epithelial cells, and club cells represent the various clusters of cells described in the single-cell RNA sequencing study. TNF=tumour necrosis factor. PFDN2=prefoldin subunit 2. PSME2=proteasome activator complex subunit 2. BTN3A2=butyrophilin subfamily 3 member A2. CAPG=macrophage-capping protein. FLT1=vascular endothelial growth factor receptor 1. CASP1=caspase-1. DDX58=antiviral innate immune response receptor RIG-I. CCL2=C-C motif chemokine 2. IL1B=antiviral innate immune response receptor RIG-I. HMOX1=heme oxygenase 1. MMP7=matrilysin.