Table 2.
Predictive signature of COVID-19 severity
| Category | Importance score | |
|---|---|---|
| Linoleamide | Metabolite | 0·0793 |
| Leukotriene A4 hydrolase | Cytokine | 0·0500 |
| Oleamide | Metabolite | 0·0440 |
| Keratin, type I cytoskeletal 19 KRT19 | Cytokine | 0·0360 |
| C-C motif chemokine 7 | Cytokine | 0·0273 |
| Heme | Metabolite | 0·0227 |
| V-set and immunoglobulin domain-containing protein 4 VSIG4 | Cytokine | 0·0213 |
| 5-methyluridine | Metabolite | 0·0167 |
| Interleukin-15 | Cytokine | 0·0160 |
| Galectin-4 | Cytokine | 0·0133 |
| Lactate | Metabolite | 0·012 |
| Prostaglandin-H2 D-isomerase | Cytokine | 0·0093 |
| C-X-C motif chemokine 9 | Cytokine | 0·0087 |
| Integrin alpha-V | Cytokine | 0·008 |
| Leucylglycine | Metabolite | 0·008 |
| Odorant-binding protein 2b | Cytokine | 0·008 |
| Prolow-density lipoprotein receptor-related protein 1 | Cytokine | 0·0073 |
| 2,6-dihydroxy-benzoic acid | Metabolite | 0·0073 |
| Phosphatidylcholine (16:0/20:1) | Lipid | 0·0067 |
| Eicosanedioate | Metabolite | 0·006 |
| Docosadienoate | Metabolite | 0·006 |
| Bilirubin (E,Z or Z,E) | Metabolite | 0·0060 |
| Keratin, type I cytoskeletal 18 | Cytokine | 0·006 |
| γ-glutamylisoleucine | Metabolite | 0·006 |
| Dipeptidase 1 | Cytokine | 0·006 |
| Insulin-like growth factor-binding protein 6 | Cytokine | 0·006 |
| 4-aminophenol sulfate | Metabolite | 0·006 |
| Phosphatidylethanolamine (P-18:1/18:1) | Lipid | 0·0053 |
| Chymotrypsin-C | Cytokine | 0·0053 |
| Membrane primary amine oxidase | Cytokine | 0·0053 |
| γ-glutamylthreonine | Metabolite | 0·0053 |
| Integrin beta-6 | Cytokine | 0·0053 |
| Glucose | Metabolite | 0·0053 |
| Kallikrein-10 | Cytokine | 0·0053 |
| PE(O-16:0/18:1) | Lipid | 0·0047 |
| Acetoacetate | Metabolite | 0·0047 |
| Cathepsin B | Cytokine | 0·0047 |
| Diacylglycerol (18:1/18:2) | Lipid | 0·0047 |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 | Cytokine | 0·0047 |
| Carcinoembryonic antigen-related cell adhesion molecule 5 | Cytokine | 0·0047 |
| ICOS ligand | Cytokine | 0·0047 |
| 4-hydroxychlorothalonil | Metabolite | 0·0047 |
| Centrosomal protein of 85 kDa | Cytokine | 0·0047 |
| Serpin B5 | Cytokine | 0·0047 |
| T-cell surface glycoprotein CD1c | Cytokine | 0·0047 |
| Heneicosapentaenoate | Metabolite | 0·0047 |
| Glycoprotein hormones alpha chain | Cytokine | 0·0047 |
| Neurotrophin-4 | Cytokine | 0·0047 |
| Ras-related protein Rab-6A | Cytokine | 0·0047 |
| Epithelial cell adhesion molecule | Cytokine | 0·0040 |
| Dipeptidyl peptidase 2 | Cytokine | 0·0040 |
| Eicosapentaenoate | Metabolite | 0·0040 |
| Leukocyte immunoglobulin-like receptor subfamily A member 5 | Cytokine | 0·0040 |
| Calcineurin subunit B type 1 | Cytokine | 0·0040 |
| Androstenediol (3α, 17α) monosulfate | Metabolite | 0·0040 |
| Arachidonate | Metabolite | 0·0040 |
| δ-carboxyethyl hydroxychroman o | Metabolite | 0·0040 |
| Cortolone glucuronide | Metabolite | 0·0040 |
| Carnitine of C10H14O2 | Metabolite | 0·0040 |
| C-type lectin domain family 6 member A | Cytokine | 0·0040 |
| Theobromine | Metabolite | 0·0040 |
| Cysteine | Metabolite | 0·0040 |
| 2-hydroxydecanoate | Metabolite | 0·0033 |
| Lysophosphatidylethanolamine (18:1) | Lipid | 0·0033 |
| Triacylglycerol 55:7-fatty acid 20:3 | Lipid | 0·0033 |
| Integrin beta-1 | Cytokine | 0·0033 |
| PE(O-16:0/22:6) | Lipid | 0·0033 |
| Dual oxidase 2 | Cytokine | 0·0033 |
| Retbindin | Cytokine | 0·0033 |
| Alpha-L-iduronidase | Cytokine | 0·0033 |
| N-methylpipecolate | Metabolite | 0·0033 |
| 4-hydroxyphenylpyruvate | Metabolite | 0·0033 |
| Hemoglobin subunit theta-1 | Cytokine | 0·0033 |
| Phosphatidylinositol (18:0/20:3) | Lipid | 0·0033 |
| Phenylacetylcarnitine | Metabolite | 0·0033 |
| Alpha-amylase 2B | Cytokine | 0·0033 |
| Cadherin-6 | Cytokine | 0·0033 |
| Ursodeoxycholate | Metabolite | 0·0033 |
| Phospholipase A2 group XV | Cytokine | 0·0027 |
| Protein GOLM2 | Cytokine | 0·0027 |
| Pentadecanoate | Metabolite | 0·0027 |
| Retinoic acid receptor responder protein 2 | Cytokine | 0·0027 |
| Angiopoietin-2 | Cytokine | 0·0027 |
| C-X-C motif chemokine 11 | Cytokine | 0·0027 |
| Pancreatic alpha-amylase | Cytokine | 0·0027 |
| Carbonic anhydrase 1 | Cytokine | 0·0027 |
| Neuropilin-1 | Cytokine | 0·002 |
| Inositol 1,4,5-triphosphate receptor associated 2 | Cytokine | 0·002 |
| Nucleoside diphosphate kinase 3 | Cytokine | 0·002 |
| Arabinose | Metabolite | 0·002 |
| Diacylglycerol (16:1/20:4) | Lipid | 0·002 |
| 3-methyl catechol sulfate | Metabolite | 0·002 |
| TBC1 domain family member 5 | Cytokine | 0·002 |
| TAG56:6-FA18:3 | Lipid | 0·002 |
| Dihydroceramide (18:1) | Lipid | 0·002 |
| Sebacate | Metabolite | 0·002 |
| EF-hand calcium-binding domain-containing protein 4B | Cytokine | 0·002 |
| Hydroxyacylglutathione hydrolase, mitochondrial | Cytokine | 0·002 |
| Cysteinyl-glycine, oxidize | Metabolite | 0·002 |
| Trizma acetate | Metabolite | 0·002 |
| Phosphatidylethanolamine (16:0/20:4) | Lipid | 0·002 |
| Cysteinylglycine disulfide | Metabolite | 0·002 |