Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The lymphatic system provides an antiferroptotic environment for metastatic tumor cells. The amounts of glutathione (GSH), vitamin E, and oleic acid are greater in lymphatic fluid than in blood. This antioxidant-rich lymphatic milieu reduces oxidative stress and the formation of lipid-reactive oxygen species, protects tumor cells from ferroptosis, and facilitates metastatic dissemination to lymph nodes and distant sites, ultimately leading to more metastases.
