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. 2022 Jul 12;297:115528. doi: 10.1016/j.jep.2022.115528

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© 2022 Published by Elsevier B.V.

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Fig. 4 — Fluorescence microscopy of infected HRT-18 cells with HCoV-OC43 (A) and betulinic acid (1) treated infected HRT-18 cells (B) at 48 hpi. Immunofluorescence staining of the nucleus with 4,6-diamidino-2-phenylindole (DAPI) (blue) and HCoV-OC43 nucleocapsid protein with Fluor488(green). The hornet's nest-like lesion (red arrows) was detected in bright field of infected HRT-18 cells with HCoV-OC43. Virions (green arrows) were detected in the ultrathin sections of HCoV-OC43 infected HRT-18 cells (C) and no viral particles were detected in betulinic acid (1) treated infected HRT-18 cells (D) at 48 hpi under electron microscope. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)