Table 3.
Pathologic features of NUT midline carcinoma.
| Case | Biopsy sites | Under naked eye | Presumptive diagnosis | Squamous cell carcinoma expression | Adenocarcinoma maker expression | Neuroendocrine marker expression | Target detection | NUT IHC result | Fish result |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Nasopharyngeal region | Hard | Poorly differentiated squamous cell carcinoma | P63(+)CK5/6(+) P40(partially+) |
TTF-1(-) | Not detected | Not detected | Positive | NUT fusion oncogene |
| 2 | Lung tumour | No vision of surgical field | Central lung cancer | P63(+) P40(+) |
TTF-1(-) | Syn(-) CgA(-) Ki-67 (60%) |
ROS-1(-) ALK-V(-) PDL1(+,100%) |
Positive | NUT fusion oncogene |
| 3 | Tracheal tumour | Hard Unclear border fish flesh appearance |
Poorly differentiated squamous cell carcinoma | P63(+) P40(+) |
TTF-1(-) NapsinA(-) |
Not detected | ROS-1(-) ALK-V(-) PDL1(-) |
Positive | NUT fusion oncogene |