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. 2022 Mar 30;40(20):2224–2234. doi: 10.1200/JCO.21.02838

FIG 4.

FIG 4.

Actionable MAPK pathway alterations by tumor type. A total of 115 alterations were detected in 112 tumors. (A) Tumor diagnoses with actionable MAPK pathway alterations identified. (B-G) Specific MAPK alterations detected in selected diagnostic groups and tumor types. The number of alterations in each group is shown. (B) All tumors, (C) non-CNS solid tumors, (D) CNS solid tumors, (E) RMS, (F) LGG, and (G) HGG. HGG, high-grade glioma; LGG, low-glade glioma; MAPK, mitogen-activated protein kinase; MPNST, malignant peripheral nerve sheath tumor; RMS, rhabdomyosarcoma.