Figure 2.

Inhibition of highly expressed PCSK9 reduced infarct size, inflammation, and myocardial fibrosis and improved cardiac function after 7 days of AMI. (a–c) Cardiac function measured by echocardiography, n = 5. (d) TTC staining showed the infarct size and quantitative analysis by ImageJ in each group, n = 5. (e) Masson staining for infarct size and myocardial fibrosis. Scale bar = 1 μm, n = 5. (f) Quantitative analysis by ImageJ for collagen volume fraction and percentage infarct size of hearts in (e). (g) HE staining for the infract regions in hearts. Scale bar = 50 μm, n = 5, and quantification of inflammatory cell infiltration. ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001; ns: not significant.