Table 1.
Characteristics of the patients at baseline
| BDG group n = 173 |
Control group n = 169 |
|
|---|---|---|
| Demographics | ||
| Age—years | 70 (58–78) | 71 (60–78) |
| Male sex—no (%) | 117 (67.6) | 105 (62.1) |
| Body mass index—kg/m2 | 26.1 (23.2–29.4) | 26 (23.1–29.7) |
| Charlson Comorbidity Index | 2 (0–3.5) | 2 (1–5) |
| APACHE II Score | 20.5 (16–25) | 20 (17–27) |
| SAPS II | 47 (39–58) | 50 (40–62) |
| SOFA-Score | 12 (10–15) | 13 (11–15) |
| Lactate levels—mmol/l | 2.8 (1.9–4.7) | 2.7 (1.7–4.5) |
| Procalcitonin levels—ng/mL | 6.5 (1.9–23.2) | 6.8 (1.8–22) |
| Patients on antimicrobial agents—no (%) | 170 (98.3) | 165 (97.6) |
| Septic shock—no (%) | 152 (87.9) | 157 (92.9) |
| Patients on mechanical ventilation—no (%) | 139 (80.3) | 138 (82.1) |
| Hospital stay before randomization—days | 5.3 (1.1–11.3) | 5.3 (1.4–10.4) |
| ICU stay before randomization—days | 0.8 (0.5–2.8) | 0.7 (0.5–1.8) |
| Time to randomization (hours) | 13.9 (8.1–20.4) | 12.6 (8.5–17.4) |
| Risk factors for invasive candida infection—no (%) | ||
| Total parenteral nutrition | 11 (6.4) | 13 (7.7) |
| Recent abdominal surgery | 117 (67.6) | 119 (70.4) |
| Recent antimicrobial therapy > 48 h | 78 (45.1) | 73 (43.2) |
| Preexisting renal replacement therapy | 15 (8.7) | 20 (11.8) |
| Sepsis etiology—no (%) | ||
| Pulmonary | 38 (22) | 40 (24) |
| Abdominal | 104 (60.1) | 109 (65.3) |
| Blood | 7 (4) | 4 (2.4) |
| Wound, skin or soft tissue | 20 (11.6) | 17 (10.2) |
| Urinary | 7 (4) | 7 (4.2) |
| Other | 13 (7.5) | 13 (7.8) |
| no infection identified | 25 (14.5) | 17 (10.2) |
| Initial blood culture positive for Candida spp.—no (%) | 8 (4.6) | 7 (4.1) |
| Initial PCR positive for Candida spp.—no (%) | 2 (1.2) | 4 (2.4) |
| Invasive Candida infection—no (%) | 25 (14.5) | 23 (13.8) |
| (1,3)-β-d-Glucan levels (baseline)—pg/mL | 73 (30–232) | 61 (30–226) |
| (1,3)-β-d-Glucan levels (day 1)—pg/mL | 58 (30–199) | 56 (30–194) |
Risk factors and sepsis etiology: multiple occurrences possible. Median (IQR) or number of patients (%) are displayed
ICU intensive care unit, APACHE acute physiology and chronic health evaluation, PCR polymerase chain reaction, SAPS simplified acute physiology score, SOFA sequential organ failure assessment