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. 2022 Jul 11;8:24. doi: 10.1038/s41526-022-00211-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Transcriptome data revealing the alterations in differentially expressed genes in paired comparisons between HU-V vs. control (a), HU-t vs. HU-v (b), and HU-t vs. control (c) groups (n = 3/group). (HU-v; hindlimb-unloaded mice treated with vehicle, HU-t; hindlimb-unloaded mice treated with 4-PBA, KCNMB4; potassium large conductance calcium-activated channel subfamily M, beta member 4, opposite strand 2, Rpl13; ribosomal protein L13 pseudogene, C2CD4B; C2 calcium-dependent domain containing 4B, ATP7B ATPase; Cu++ transporting beta polypeptide, CACNG8; calcium channel voltage-dependent gamma subunit 8, CAMK4; calcium/calmodulin-dependent protein kinase IV, Nfatc2; nuclear factor of activated T cells, cytoplasmic calcineurin dependent 2 interacting protein, Mtfr1; mitochondrial fission regulator 1, Mapk6; mitogen-activated protein kinase 6, HDAC7; histone deacetylase 7, HSP1; heat shock protein 1, CAPN15; calpain 15, P4HA2; procollagen-proline 2-oxoglutarate 4-dioxygenase alpha II polypeptide, MAMSTR; MEF2 activating motif and SAP domain containing transcriptional regulator, BMP1; bone morphogenetic protein 1, JAK3; Janus kinase 3, FGF3; fibroblast growth factor receptor 3, CatK; cathepsin K, eNOS3; nitric oxide synthase 3 endothelial cell, Amigo2; adhesion molecule with Ig like domain 2, Cacna1g; calcium channel, voltage-dependent T type alpha 1G subunit, ARHGAP4; Rho GTPase activating protein 4, ARHGAP25; Rho GTPase activating protein 25, MMP3; matrix metallopeptidase 3, ICAM2; intercellular adhesion molecule 2, HPS3; HPS3 biogenesis of lysosomal organelles complex 2 subunit 1, Dkk-3; dickkopf WNT signaling pathway inhibitor 3, ASB14; ankyrin repeat and SOCS box-containing 14, PLVAP; plasmalemma vesicle associated protein, RAMP2; receptor (calcitonin) activity modifying protein 2, Eif2s3y; eukaryotic translation initiation factor 2 subunit 3 structural gene Y-linked, MTFR1; mitochondrial fission regulator 1, CARHSP1; calcium regulated heat stable protein 1, Mapk6; mitogen-activated protein kinase 6, Hsp90aa; heat shock protein 90, alpha (cytosolic) class A member 1, CPT1; carnitine palmitoyltransferase 1c, HSP1; heat shock protein 1-like, DNAI2; dynein, axonemal, intermediate chain 2, Arhgap33os; Rho GTPase activating protein 33 opposite strand, CABYR; calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2), Mapk10; mitogen-activated protein kinase 10, DKKL1; dickkopf-like 1, CAMK4;calcium/calmodulin-dependent protein kinase IV, Serp2; stress-associated endoplasmic reticulum protein family member 2, CABCOCO1; ciliary associated calcium binding coiled-coil 1, BMP8b; bone morphogenetic protein 8b, EFCAB5; EF-hand calcium binding domain 5, HSF5; heat shock transcription factor family member 5, Gm11266; predicted gene 11266, 1700001O22Rik; RIKEN cDNA 1700001O22 gene, Ssc5d; scavenger receptor cysteine rich family 5 domains, Hspa1b; heat shock protein 1B, Cacna1g; calcium channel voltage-dependent T type alpha 1G subunit, Actc1;actin alpha cardiac muscle 1, Slc25a25, solute carrier family 25 (mitochondrial carrier, phosphate carrier) member 25, Gm28439; predicted gene 28439, mt-Tq; mitochondrial encoded tRNA glutamine, Zdhhc19; zinc finger DHHC domain containing 19, Mroh5; maestro heat-like repeat family member 5, Gzmn; granzyme N).