Table 1.
Clinical characteristics of participants with IBD and controls.
| Characteristics | Ulcerative colitis (n = 19) | Crohn’s disease (n = 41) | All IBD (n = 63) | Controls (n = 63) | All IBD and Controls OR (95% CI), p value |
|---|---|---|---|---|---|
| Age (median (IQR), years) | 43 (24) | 49 (43) | 48 (21) | 47 (25) | 1.00 (0.98 to 1.02), p = 0.89 |
| Sex | |||||
| Female, n (%) | 9 (47) | 19 (46) | 29 (47) | 29 (46) | 1.00 (0.50 to 2.02), p = 1.00 |
| Male, n (%) | 10 (53) | 22 (54) | 34 (53) | 34 (54) | |
| Ancestry | |||||
| Northern European, n (%) | 10 (53) | 32 (78) | 45 (71) | 45 (71) | 1.00 (0.46 to 2.17), p = 1.00 |
| Southern European, n (%) | 7 (37) | 9 (22) | 16 (25) | 16 (25) | 1.00 (0.45 to 2.23), p = 1.00 |
| Asian, n (%) | 2 (11) | 0 | 2 (3) | 2 (3) | 1.00 (0.14 to 7.33), p = 1.00 |
| Co-morbidities | |||||
| Hypertension, n (%) | 3 (16) | 7 (17) | 11 (17) | 24 (38) | 0.33 (0.15 to 0.79), p = 0.02 |
| Smoking history, n (%) | 9 (47) | 25 (61) | 8 (13) | 39 (62) | 0.09 (0.04 to 0.22), p = 0.70 |
| Diabetes, n (%) | 5 (26) | 3 (7) | 36 (57) | 10 (16) | 7.07 (3.05 to 16.37), p = 0.60 |
| Laboratory indices | |||||
| CRP (median (IQR), mg/L) | 5 (15) | 7 (14) | 7(14) | 10 (46) | p = 0.12 |
| Serum albumin (median (IQR), g/L) | 36 (7) | 37 (6) | 37(6) | 37 (7) | p = 0.84 |
| eGFR (median (IQR), ml/min/1.73 m2) | 90 (17) | 90 (14) | 90 (15) | 90 (0) | p = 0.08 |
| IBD features | |||||
| Disease duration (median (IQR), years) | 8 (11) | 7 (12) | 7 (10) | ||
| Anatomical distribution | |||||
| Ulcerative colitis (n = 18) | |||||
| Proctosigmoiditis, n (%) | 8 (44) | ||||
| Extensive left sided colitis, n (%) | 4 (22) | ||||
| Pancolitis, n (%) | 6 (33) | ||||
| Crohn’s disease (n = 41) | |||||
| Small bowel only, n (%) | 13 (32) | ||||
| Colonic involvement, n (%) | 28 (68) | ||||
| Complications (n = 28) | 4 (21) | 23 (55) | 27 (43%) | ||
| Fistula, n (%) | 0 | 2 (5) | 2 (3%) | ||
| Stricture, n (%) | 0 | 14 (35) | 14 (22%) | ||
| Perianal disease, n (%) | 1 (%) | 1 (3) | 2 (3%) | ||
| Small bowel obstruction, n (%) | 0 | 5 (13) | 5 (8%) | ||
| Bowel resection, n (%) | 2 (6) | 11 (28) | 13 (21%) | ||
| Adenomas, n (%) | 0 | 2 (5) | 2 (3%) | ||
| Bowel cancer, n (%) | 0 | 1 (3) | 1 (2%) | ||
| Extraintestinal manifestations, n (%) | 5 (28) | 8 (20) | 13 (21%) | ||
All IBD included participants with UC, CD or indeterminate disease; Anatomical distribution was not known in one individual with ulcerative colitis and five with Crohn’s disease. N/A not applicable.
Significant values are in bold.