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. 2022 Jul 11;12:11748. doi: 10.1038/s41598-022-15640-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcript expression profiles of control, TGFß1-treated and TNFα-treated MEFs using RNA microarrays. (a) Heatmap summarizing DEGs in TGFß1- (5 ng/ml) or TNFα- (10 ng/ml) treated MEFs for 24 h compared to controls (untreated MEFs) (q-value < 0.05) after normalization with Z-score. Hierarchical clustering was constructed with Euclidean distance using R software. N = 3 biological replicas (3 independent experiments). (b–c) Enrichment analysis summarizing the most representative up-regulated pathways in TGFß1_up^genes (b) and TNFα_up^genes (c) using Metascape (http://metascape.org/gp/index.html#/main/step1).