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. 2022 Jul 11;12:11748. doi: 10.1038/s41598-022-15640-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene signature expression assessed by RT-qPCR in HOCL mice and in PBS mice at day 7 and day 42. (a) Heatmap showing the transcript gene set expression assessed by RT-qPCR from (i) TNFα-treated MEFs (compared to control MEFs), (ii) TGFß1-treated MEFs (compared to control MEFs), (iii) d₇HOCL MPFs (compared to d₇PBS MPFs), and (iv) d₄₂HOCL MPFs (compared to _d42PBS MPFs). Fold changes are log2-transformed and expressed as a double gradient colormap. Log2 values of fold changes are censored at -5 or 5 for better viewing. The heatmap was generated using Prism (https://www.graphpad.com/scientific-software/prism/), (b) RT-qPCR results. Numbers are expressed as median fold change (IQR) compared to PBS at day 7 or day 42. P-value: *** ≤ 0.001, ** ≤ 0.01, * ≤ 0.05. ns: > 0.05.