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Illustration of the possible mechanism underlying hesperetin-induced apoptosis in GL261 cells. TNF-α, tumor necrosis factor-α; TNFR1, tumor necrosis factor-α receptor 1; NF-κB, nuclear factor-kappa B; PARP, Polyadenosine-diphosphate-ribose polymerase; PI3K, Phosphoinositide 3-kinase; AKT1, protein kinase B1; BCL -2, B cell lymphoma-2; BAX, BCL-2 associated X protein, CytoC, cytochrome c.
