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. 2022 Jun;11(6):1781–1794. doi: 10.21037/tcr-22-1497

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2022 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Hesperetin downregulated the expression of MMP-9 and MMP-2. GL261 cells were treated with hesperetin at indicated concentrations for 24 h. Western blotting was used to detect the expression of MMP-9 and MMP-2. Representative western blots present target protein expression. Protein expression of MMP-9 and MMP-2 were quantified by densitometry and normalized to GAPDH (n≥3). *, P<0.05 and ***, P<0.001 compared with the respective control group. MMP, matrix metalloproteinase. C represents control group (without HSP treatment). GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HSP, hesperetin.