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. 2022 Jun;11(6):1488–1502. doi: 10.21037/tcr-22-242

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2022 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Underexpressed ETC genes were associated with tumor metastasis process and higher immune responds. (A) Gene expression of ETC genes. Positive logFC represents higher expression and negative logFC represents lower expression in mRCC. (B) A heatmap showing gene expression of each sample. The cell types were shown blow. (C) The differential enriched pathway based on GSVA result. (D) The GSVA score of each sample in differential enriched pathway based on GSVA result. (E,F) The GSEA results of TCGA sample based on ETC gene expression. FC, fold change; mRCC, metastatic renal cell carcinoma; pRCC, primary renal cell carcinoma; ETC, electron transport chain; GSVA, gene set variation analysis; GSEA, gene set enrichment analysis; TCGA, The Cancer Genome Atlas.