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. 2022 Jun 28;13:885424. doi: 10.3389/fimmu.2022.885424

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Copyright © 2022 Zhong, Lu, Ma, He, Ding, Yao, Zhou, Dong, Fang, Jiang, Wang and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isolation of anti-CLDN18.2 VHH variants. (A) Amino acid sequences of anti-CLDN18.2 VHHs. Sequences are presented using one-letter amino acid abbreviations. DNAMAN was used to generate the alignment. Complementarity determining regions (CDRs) are shown. Four hydrophilic amino acids (Tyr42, Glu/Gln49, Arg50 and Leu/Phe52) critical for humanization are indicated with red arrows. (B) Schematic composition of hu7v3-Fc structure in this study. Anti CLDN18.2 VHH hu7v3 is indicated in orange, and the human IgG1 Fc domain including the hinge, CH2 and CH3 domains is indicated in gray.