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. 2022 Jun 28;13:885424. doi: 10.3389/fimmu.2022.885424

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Copyright © 2022 Zhong, Lu, Ma, He, Ding, Yao, Zhou, Dong, Fang, Jiang, Wang and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of anti-CLDN18.2 hu7v3-Fc. (A) Flow cytometric analysis to determine the specificity of hu7v3-Fc to CLDN18.2. Zolbetuximab was employed as the positive control antibody, and human IgG1 isotype as the negative control antibody. CLDN18.1 and CLDN18.2 was co-expressed with GFP in CHO-CLDN18.1-GFP and CHO-CLDN18.2-GFP cells, respectively. (B) IHC analysis to determine the specificity of hu7v3-Fc to CLDN18.2. Frozen sections of colon, brain, lung, lymph node, ovary, skin parotid gland, kidney, liver, pancreas, stomach antrum and stomach body were obtained from healthy tissue in The First Affiliated Hospital of Zhejiang University.