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. 2022 Jul 11;9:395. doi: 10.1038/s41597-022-01512-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Significantly upregulated and downregulated proteins upon 7 days Palbociclib treatment of MDA-MB-231. (a) Proteins with significantly different expression in total proteome of MDA-MB-231 7 days Palbociclib-treated cells (both FBS and starved samples) as compared to their respective DMSO-treated controls. (b) Significantly different phosphorylation profile of proteins in MDA-MB-231 7 days Palbociclib-treated cells (both FBS and starved samples) as compared to their respective DMSO-treated controls. (c) Significantly different expression of proteins in secretome of 7 days Palbociclib-treated versus DMSO-treated MDA-MB-231 cells. In all cases, one sample t-test was performed and subsequent results were filtered for q-value < 0.05 using Perseus software³⁹. Top 50 most significant hits were calculated with the Manhattan metric using VolcaNoseR (R2 mirror)⁴⁰. Log2FC = Log2 Fold Change.