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. 2022 Jul 11;9:395. doi: 10.1038/s41597-022-01512-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — KEGG pathway enrichment of significantly upregulated proteins in 7 days treated Palbociclib MDA-MB-231 samples (FBS and starved samples) versus their respective DMSO control samples. (a) Top 10 most upregulated KEGG pathways as determined by a Fisher’s exact test (Benjamini-Hochberg FDR threshold = 0.05) on 1 sample t-test results where a column indicating upregulation (Log2FC > 0.5) or downregulation (Log2FC < −0.5) was added. (b) Log2FC of upregulated proteins in the top 10 upregulated KEGG pathways which are disease or immune-related (Asthma, Autoimmune thyroid disease, Graft-versus-host disease, Allograft rejection, Intestinal immune network for IgA production, Type I diabetes mellitus and Staphylococcus aureus infection). Log2FC of 7 days Palbociclib-treated samples (FBS and starved) compared to their respective DMSO controls (FBS and starved) was calculated using a one sample t-test and subsequent results were filtered for q-value < 0.05 using Perseus software³⁹. (c) Total protein scaled abundances for the proteins in Top 10 upregulated KEGG pathways which are disease or immune-related. (d) Log2FC of proteins in the KEGG pathway named Antigen processing and presentation. Log2FC = Log2 Fold Change.