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Mechanism of Nano-PMI@CeO2 in vivo induced tumor cell death. (A) Schematic diagram for antitumor activity of Nano-PMI@CeO2 targeting the p53 pathways and inducing ferroptosis. (B) Representative IHC staining of COX2, GPX4, and p53 in tumor sections. (Scale bar:100 μm). (C) IHC scores analysis presented intratumoral protein levels of p53, GPX4, and COX2. p values were calculated by t-test (*, p < 0.05; **, p < 0.01; ***, p < 0.001).
