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. 2022 Jun 28;14:885787. doi: 10.3389/fnagi.2022.885787

Table 3.

The sex specific relation of diabetes with cognitive performance in older men and women (N = 893).

Men Women Interactiona p-valueb
B (95% CI) B (95% CI) B (95% CI)
Memory
Non-diabetic Ref Ref Ref
Diabetic (model 1) 0.02 (−0.09 to 0.03) 0.02 (−0.07 to 0.03) 0.09 (−0.26 to 0.46) 0.59
Diabetic (model 2) 0.03 (−0.09 to 0.02) 0.02 (−0.07 to 0.03) 0.10 (−0.26 to 0.47) 0.57
Diabetic (model 3) 0.03 (−0.08 to 0.02) 0.01 (−0.06 to 0.03) 0.10 (−0.27 to 0.47) 0.59
Executive function
Non-diabetic Ref Ref
Diabetic (model 1) −0.02 (−0.09 to 0.04) −0.07 (−0.14 to 0.00)* −0.04 (−0.36 to 0.28) 0.81
Diabetic (model 2) −0.02 (−0.09 to 0.04) −0.06 (−0.13 to 0.01) −0.03 (−0.32 to 0.32) 0.98
Diabetic (model 3) −0.01 (−0.06 to 0.06) −0.07 (−0.13 to 0.00)* −0.01 (−0.33 to 0.32) 0.97
Processing speed
Non-diabetic Ref Ref
Diabetic (model 2) −0.03 (−0.08 to 0.01) −0.06 (−0.10 to 0.02)* 0.19 (0.03 to 0.34) 0.02
Diabetic (model 3) −0.03 (−0.08 – 0.02) −0.06 (−0.10 to 0.01)* 0.18 (0.02 to 0.33) 0.03
Diabetic (model 1) −0.02 (−0.07 to 0.01) −0.06 (−0.10 to 0.02)* 0.17 (0.03 to 0.33) 0.04
Language
Non-diabetic Ref Ref
Diabetic (model 1) −0.01 (−0.06 to 0.04) −0.07 (−0.12 to 0.01)* −0.18 (−0.53 to 0.17) 0.31
Diabetic (model 2) −0.01 (−0.05 to 0.07) −0.06 (−0.12 to 0.00) −0.12 (−0.48 to 0.22) 0.14
Diabetic (model 3) 0.00 (−0.05 to 0.04) −0.07 (−0.012 to 0.01)* −0.14 (−0.49 to 0.21) 0.43

Data are presented as unstandardized B with (95% CI).

A negative B signifies a correlation with worse Z-scores, e.g. with worse cognitive performance.

Model 1: adjusted for age and level of education; Model 2: adjusted for age, level of education, smoking and alcohol consumption; Model 3: Adjusted for age, level of education, presence of CVD (coronary disease, heart failure, atrial fibrillation, CVA or TIA, peripheral arterial disease), hypertension and hypercholesterolemia.

*p-value linear regression < 0.05.

aInteraction term (sex multiplied by diabetes) added to the logistic regression.

bStatistical significance of the interaction term in the logistic regression analysis.

The bold values indicate the p values which are statistically significant.