FIGURE 1.

Flowchart for ALS target discovery and drug repurposing. Target identification was performed with the public CNS tissue-based datasets, and diMN data from Answer ALS on PandaOmics. Targets were divided into two categories: novel targets for further investigation and targets for drug repurposing. The targets will be released onto ALS.AI. Feedback on proposed targets will be collected from ALS KOLs to select the best candidates for further validation. The identified targets will be further validated using in vivo and in vitro models. The combined usage of PandaOmics and ALS.AI significantly reduces the time required for novel target discovery and drug investigation for ALS treatment, which points to a potential direction to search for the treatment of other human diseases.