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. 2022 Jun 28;14:914017. doi: 10.3389/fnagi.2022.914017

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Copyright © 2022 Pun, Liu, Long, Leung, Leung, Mewborne, Gao, Shneyderman, Ozerov, Wang, Ren, Aliper, Bischof, Izumchenko, Guan, Zhang, Lu, Rothstein, Cudkowicz and Zhavoronkov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed targets in ALS-associated pathways. Several proposed targets, labeled in green, were presented in pathways related to ALS pathogenesis, including neuronal cell death, oxidative stress, neuroinflammation, and proteostasis dysfunction. Information of associated networks was retrieved from KEGG ALS pathway (map05014), Protein processing in endoplasmic reticulum (map04141), T cell receptor signaling pathway (map04660), Ubiquitin mediated proteolysis (map04120), and Pentose phosphate pathway (map00030).