TABLE 1.

ALS case-control comparisons using CNS and diMN samples.

Subtype	Data series	Platform	Technology	Source	Mutant gene	# Case	# Control	Year	References
CNS comparisons
fALS	E-MTAB-1925	A-MEXP-2246	Microarray	Motor Cortex	C9orf72	3	3	2013	Donnelly et al., 2013
fALS	GSE67196	GPL11154	RNA-seq	Cerebellum	C9orf72	8	8	2015	Prudencio et al., 2015
fALS	GSE67196	GPL11154	RNA-seq	Frontal Cortex	C9orf72	8	9	2015	Prudencio et al., 2015
fALS	GSE68605	GPL570	Microarray	Motor Neurons	C9orf72	8	3	2015	Cooper-Knock et al., 2015
fALS	GSE20589	GPL570	Microarray	Motor Neurons	SOD1	3	7	2010	Kirby et al., 2011
sALS	GSE122649	GPL18573	RNA-seq	Motor Cortex	–	26	12	2018	Tam et al., 2019
sALS	GSE124439	GPL16791	RNA-seq	Frontal Cortex	–	65	9	2018	Tam et al., 2019
sALS	GSE124439	GPL16791	RNA-seq	Motor Cortex	–	80	8	2018	Tam et al., 2019
sALS	GSE19332	GPL570	Microarray	Motor Neurons	–	3	7	2009	Cox et al., 2010
sALS	GSE76220	GPL9115	RNA-seq	Spinal Motor Neurons	–	13	8	2015	Krach et al., 2018
sALS	GSE67196	GPL11154	RNA-seq	Cerebellum	–	10	8	2015	Prudencio et al., 2015
sALS	GSE67196	GPL11154	RNA-seq	Frontal Cortex	–	10	9	2015	Prudencio et al., 2015
diMN transcriptomic comparisons
fALS	Answer ALS	Novaseq 6000	RNA-seq	diMN	–	25	31	2022	Baxi et al., 2022
sALS	Answer ALS	Novaseq 6000	RNA-seq	diMN	–	110	31	2022	Baxi et al., 2022
diMN proteomic comparisons
fALS	Answer ALS	SCIEX 6600	SWATH-MS	diMN	–	25	31	2022	Baxi et al., 2022
sALS	Answer ALS	SCIEX 6600	SWATH-MS	diMN	–	110	31	2022	Baxi et al., 2022