TABLE 3.

Screen results using a c9ALS Drosophila model.

Human symbol	Fly symbol	Availability of fly model	Score	Interpretation	References
KCNB2	Shab	Yes	−3.5	Strong rescue	–
KCNS3	Shab	Yes	−3.5	Strong rescue	–
VCP	TER94	Yes	−3.5	Strong rescue	Zhang et al., 2015
ADRA2B	Octα2R	Yes	−3	Strong rescue	–
NR3C1	ERR	Yes	−3	Strong rescue	–
P2RY14	AstC-R1	Yes	−3	Strong rescue	–
	AstC-R2	Yes	−2	Moderate rescue	–
PPP3CB	Pp2B-14D	Yes	−3	Strong rescue	–
	CanA-14F	Yes	−2	Moderate rescue	–
PTPRC	Ptp69D	Yes	−3	Strong rescue	–
RARA	Eip78C	Yes	−3	Strong rescue	–
	EcR	Yes	−2.5	Moderate rescue	–
	Hr96	Yes	−2	Moderate rescue	–
	Eip75B	Yes	Lethal	–	–
PTK2	Fak	Yes	−2.5	Moderate rescue	–
AHCYL1	AhcyL1	Yes	−2	Moderate rescue	–
DNMT3A	ADD1	Yes	−2	Moderate rescue	–
	sba	Yes	0	No modification	–
ERN1	Ire1	Yes	−2	Moderate rescue	–
MAP3K5	Ask1	Yes	−2	Moderate rescue	–
MAPK1	rl	Yes	−2	Moderate rescue	–
SCYL1	yata	Yes	−2	Moderate rescue	–
STUB1	STUB1	Yes	−2	Moderate rescue	–
TOPORS	Topors	Yes	−2	Moderate rescue	–
G6PD	Zw	Yes	−1	Mild rescue	–
NOS1	Nos	Yes	−1	Mild rescue	–
HSPD1	Hsp60A	Yes	−0.5	No modification	–
CYBB	Duox	Yes	0	No modification	–
PSMC6	Rpt4	Yes	0	No modification	Zhang et al., 2015
PPIA	CG7768	Yes	0.5	No modification	Neuro et al., 2021
	Cyp1	Yes	0.5	No modification	Neuro et al., 2021
FLT1	Pvr	Yes	1	Mild enhancement	Neuro et al., 2021
RPS6KB1	S6k	Yes	2	Moderate enhancement	–
METTL21A	CG5013	No	–	–	–
SLC25A10	Dic1	No	–	–	–

Both KCNB2 and KCNS3 correspond to Shab in Drosophila. A score of −3.5 stood for the situation that some offspring flies were scored −4 and some were −3. The same applies to the scores of −2.5, −0.5 and 0.5.