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. 2022 Jun 28;13:930041. doi: 10.3389/fphar.2022.930041

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Copyright © 2022 Lv, Liu, Zeng, Liu, Zhang, Zhang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression pattern of cuproptosis-related genes and survival and functional enrichment analysis in two Skin Cutaneous Melanoma (SKCM) clusters. (A) Consensus clustering matrix for k = 2. (B) Box plots visualized the expression patterns of cuproptosis-related genes in two SKCM clusters. (C) The heatmap of the differential gene expression between two SKCM clusters. (D–F) The most significant KEGG pathways (D), GO enrichment (E) and activation of multiple pathways by GSVA (F) in two SKCM clusters. (G) The Kaplan–Meier curves show the overall survival for two clusters of SKCM patients. **p < 0.01, and ***p < 0.001.