Figure 1.

Structure of liver sinusoidal microenvironment. As the gatekeeper of hepatic sinusoidal microenvironment, LSECs constitute the interface between the sinusoid and blood flow. The intercellular crosstalk between LSECs and various cells including hepatocytes, lymphocytes, neutrophils, macrophages, and hepatic stellate cells, which together consist of the hepatic microenvironment.