Table 1.

Therapeutic drugs related to crosstalk between LSECs and other sinusoidal cells involved in this paper.

Target	Drug	Mechanisms	References
adhesion-related molecules	Cenicriviroc TERN-201	ameliorating hepatic inflammation reducing the recruitment of CCR2+ monocyte in the liver inhibiting VAP-1 to control inflammation in NASH	(65, 127)
NO-related signaling	Statins WAY-362450 Praliciguat	ameliorating the LSECs phenotype that improves HSCs status by paracrine manner promoting ADMA degradation and recovery of NO pathway increasing the cGMP level in LSECs	(117, 128–131)
angiogenesis	L1-10 AAV9 with shRNA of LECT2 combined with recombinant VEGF or bevacizumab	preventing sinusoidal capillarization inhibiting the interaction between LECT2 and its receptor Tie1 inhibiting VEGF/VEGFR signaling	(132–134)