TABLE 12.

Application of HPLC-ICP-MS in Chinese patent medicine.

Name	Medical system	The main medicinal materials	Therapeutic use	Main pharmacological effects	Test results
Huoxue Zhitong Capsules	Traditional Chinese medicine	Angelica sinensis (Oliv.) Diels, Boswellia sacra Flück., Borneol, Natural copper, Panax notoginseng (Burkill) F.H.Chen	Traumatic injury, hemostasis, swelling, pain	Anti-inflammation and analgesia	Soluble arsenic and valence arsenic AsC, AsB, AsⅢ, DMA, MMA, and AsV in seven batches of Huoxue Zhitong Capsules were determined. Only AsⅢ was detected in six valence arsenic (Chen and Zhang, 2019)
Jiegu Qili tablets	Traditional Chinese medicine	Angelica sinensis (Oliv.) Diels, Boswellia sacra Flück., Calamus draco Willd. Ground beetle, Myrrh, Rheum tanguticum (Maxim. ex Regel) Balf.	Cataclasis	Improve hemorheology	The content of total arsenic in Jiegu Qili tablets was determined. The linear range of total arsenic mass concentration was 2.0–20.0 ng/ml (r = 0.9992). The detection limit was 0.0016 ng/ml. The recovery was 98.23%–99.95%, and the RSD was less than 3.5% 25% (n = 3). AsB, AsC, MMA, DMA, As Ⅲ, and As Ⅴ have good linear relationship (r > 0.999), the detection limit is 0.0029–0.0103 ng/ml, the recovery is 89.15%–95.5% 89%, and RSD is less than 7.14% (n = 3). Jiegu Qili tablet contains MMA, DMA, As Ⅲ, and As Ⅴ, in which the content of As Ⅴ is the highest, followed by As Ⅲ, and a small amount of MMA and DMA (Zhu et al., 2020)
Niuhuang Jiedu tablets	Traditional Chinese medicine	Bezoar, Borneol, Glycyrrhiza uralensis Fisch. ex DC., Platycodon grandiflorus (Jacq.) A.DC., Plaster, Realgar, Rheum tanguticum (Maxim. ex Regel) Balf., Scutellaria baicalensis Georgi	Sore throat, sore gums, sore tongue, swelling, and pain	Antioxidant, antiviral, anti-tumor, anticonvulsant, antiepileptic	The detection limits of AsB, DMA, As Ⅲ, MMA, and As Ⅴ were 0.05, 0.05, 0.08, 0.10, and 0.10 μg/L, respectively. Linear correlation coefficient R 2 > 0.999. The recovery was 86.3%–109.2%, and the RSD was less than 5% (Chen et al., 2017)
Xiaoer Kechuanling granules	Traditional Chinese medicine	Ephedra equisetina Bunge, Glycyrrhiza uralensis Fisch. ex DC., Lonicera japonica Thunb., Plaster, Strobilanthes cusia (Nees) Kuntze, Prunus sibirica L., Trichosanthes kirilowii Maxim.	Cough caused by upper respiratory tract infection	Antiviral, anti-inflammatory, antioxidant, and anticoagulant	The contents of Cr (Ⅲ) and Cr (Ⅵ) in Xiaoer Kechuanling granules were determined. Cr (Ⅲ) and Cr (Ⅵ) were in the range of 5–100 μg·g−1, r > 0.999, the recovery of Cr (VI) was 82.1%–90.4%. The recovery of Cr (Ⅲ) was 94.1%–95.2%. Cr (VI) was detected in eight batches of samples, the detection value was 0. 027–0. 082 μg·g−1, the average value is 0.051 μg·g−1, the detected value of Cr (Ⅲ) is 5.775–18.743 μg·g−1, and the average value is 10.366 μg·g−1 (Chen et al., 2020f)