Table 4. HHI over time by line of therapy (limited to sites with ≥10 patients).

Grouped by year	Patients	Sites	HHI score					P value
			Mean	Standard deviation	Median	Min	Max
1L
2011–2012	197	12	0.1946	0.0531	0.1771	0.1357	0.3156	0.25*
2013–2014	571	25	0.1930	0.0881	0.1851	0.1116	0.5690
2015–2016	739	34	0.2291	0.0953	0.1950	0.1074	0.5400
2017–2018	536	27	0.2161	0.0807	0.1901	0.1296	0.4438
2L
2011–2012	24	2	0.1561	0.0621	0.1561	0.1122	0.2000	0.17*
2013–2014	246	16	0.1397	0.0402	0.1312	0.0892	0.2089
2015–2016	324	19	0.1803	0.0773	0.1531	0.1029	0.4000
2017–2018	123	7	0.1961	0.0791	0.1735	0.1332	0.3633

*, linear regression was performed on the trend analysis. HHI, Herfindahl-Hirschman index; 1L, first-line; 2L, second-line.