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. 2022 Jun;13(3):958–967. doi: 10.21037/jgo-22-341

Figure 2.

Figure 2

Knocked down ARF6 only initiated lipid peroxidation when erastin was present. (A) MDA levels were determined in AR6-silenced BGC-823 cells both treated and not treated with erastin (2 µM). (B) MDA levels were determined in AR6-silenced MGC80-3 cells both treated and not treated with erastin. (C) Confocal imaging (×40) revealed nuclear (blue) and oxidized (green) lipids in the ARF6-silenced BGC-823 and MGC80-3 cells both treated and not treated with erastin (2 µM) and stained with DAPI. *, P<0.05; **, P<0.01. ARF6, ADP ribosylation factor 6; MDA, malondialdehyde; DAPI, 4',6-diamidino-2-phenylindole.