Table 2. Comparison of the clinicopathological variables between the groups with or without PHLF after hepatectomy.
| Variable | PHLF (n=58) | NPHLF (n=156) | P value |
|---|---|---|---|
| Gender (female/male) | 7/51 | 26/130 | 0.408 |
| Age (y) | 57.0±11.2 | 59.0±8.1 | 0.205 |
| BMI (kg/m2) | 22.4±2.8 | 22.2±2.8 | 0.643 |
| Etiology of hepatectomy | 0.128 | ||
| Benign | 4 (6.9) | 4 (2.6) | |
| Primary hepatic carcinoma | 53 (91.4) | 142 (91.0) | |
| Metastasis | 1 (1.7) | 10 (6.4) | |
| ASA | |||
| I | 56 (96.6) | 152 (97.4) | 0.663 |
| II | 2 (3.4) | 4 (2.6) | |
| Background liver disease | 0.526 | ||
| HBV | 57 (98.3) | 151 (96.8) | |
| HCV | 1 (1.7) | 3 (1.9) | |
| Alcoholic liver cirrhosis | 0 (0.0) | 2 (1.3) | |
| Laboratory data | |||
| HGB (g/L) | 115.1±17.2 | 120.8±13.9 | 0.027 |
| Platelet count (109/L) | 180.7±125.1 | 176.0±107.1 | 0.787 |
| TB (μmol/L) | 19.9±14.5 | 23.9±15.4 | 0.089 |
| DB (μmol/L) | 11.3±9.5 | 13.4±9.2 | 0.144 |
| ALT (U/L) | 38.6±19.4 | 49.8±37.6 | 0.005 |
| AST (U/L) | 43.6±24.0 | 46.4±31.4 | 0.536 |
| ALB (g/L) | 38.5±4.8 | 38.4±5.3 | 0.869 |
| INR | 0.94±0.15 | 1.00±0.19 | 0.021 |
| Liver cirrhosis | 49 (84.5) | 125 (80.1) | 0.468 |
| Status of liver function | |||
| Child-Pugh score, median [min–max] | 5.0 [5–7] | 5.0 [5–7] | 0.927 |
| ICG-R15 (%) | 10.3±3.4 | 7.0±3.7 | 0.000 |
| Tumor diameter (cm) | 8.1±3.0 | 6.3±2.5 | 0.000 |
| PRLV/SLV (%) | 57.4±10.5 | 65.4±10.3 | 0.000 |
| Clavien-Dindo classification, n (%) | |||
| Mild-moderate (grade I–II) | 29 (50.0) | 27 (17.3) | 0.000 |
| Severe (grade III–V) | 17 (29.3) | 2 (1.3) | 0.000 |
| Preoperative TACE | 6 (10.3) | 4 (2.6) | 0.026 |
| Operative time (min) | 314.3±70.1 | 286.8±75.5 | 0.017 |
| Blood loss (mL) | 265.5±158.4 | 244.2±150.4 | 0.365 |
| Postoperative hospital stay (day) | 14.3±2.8 | 7.1±1.4 | 0.000 |
Data are indicated n (%), median [IQR] or . PHLF, post-hepatectomy liver failure; NPHLF, non post-hepatectomy liver failure; BMI, body mass index; ASA, American Society of anesthesiologists; HBV, hepatitis B virus; HCV, hepatitis C virus; TACE, transcatheter arterial chemoembolization; HGB, hemoglobin; TB, total bilirubin; DB, direct bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; INR, international normalized ratio; PRLV, predicted residual liver volumes; SLV, standard liver volume.