FIGURE 2.

NLRP3 activation triggers the inflammatory pathway of atherosclerosis in monocytes and macrophages resident cells. The ischemic insult due to ischemia and reperfusion after acute myocadial infarction activates the inflammatory pathway mediated by NLRP3. ROS—reactive oxygen species; NLRP3 - nucleotide-binding and oligomerization-like receptor pyrin domain-containing protein 3; IL—interleukin; SAA—serum amyloid A; CRP—C-reactive protein; TNF-alpha—tumour necrosis factor—alpha; PAI-1—plasminogen activator inhibitor type 1. NLRP3 inflammasome is a common inflammatory platform where many stimuli (e.g., cholesterol crystals, ischemic conditions) can activate IL-1beta triggering the inflammatory pathway, including IL-6. The activation of IL-1beta reduces contractility in response to beta adrenergic stimuli and is associated with ventricular remodeling. Further, increase in CRP levels can be used for monitoring of the low-grade inflammation.